LANDMARK PAPERS IN ANAESTHESIA, BY THEME

ANAESTHETIC FUNDAMENTALS

AIRWAY MANAGEMENT

Transnasal Humidified Rapid‐Insufflation Ventilatory Exchange (THRIVE)

NAP4 – airway complications

ANAESTHETIC PROCEDURES

CRISIS MANAGEMENT, RESUSCITATION & FLUID MANAGEMENT

RELIEF

Preemptive hemodynamic intervention to improve postoperative outcomes

An improved paradigm for prescribing intravenous fluid therapy

Perioperative fluid management strategies in major surgery

NAP6 – anaphylaxis

Association between intraoperative blood transfusion and mortality and morbidity

Association of intraoperative hypotension with acute kidney injury

Oxidative stress and mitochondrial dysfunction in sepsis

Diagnostic accuracy of pulse pressure variations for the prediction of fluid responsiveness

Inflammatory response, immunosuppression, and cancer recurrence after blood transfusions

POISE-II

SAFE

GENERAL ANAESTHESIA & SEDATION

Relationship between intraoperative mean arterial pressure and clinical outcomes

BALANCED

ENIGMA-II

NAP5 – awareness

ENIGMA

B-AWARE

BIS-guided anesthesia decreases postoperative delirium and cognitive decline

Protective mechanical ventilation during general anesthesia improves postoperative pulmonary function

Monitoring depth of anaesthesia decreases the rate of postoperative delirium but not postoperative cognitive dysfunction

Evidence-based analysis of risk factors for postoperative nausea and vomiting

Protective versus conventional ventilation for surgery

Hospital stay and mortality are increased in patients having a ‘triple low’

Postoperative cognitive dysfunction is independent of type of surgery and anesthetic

Long-term survival for patients undergoing volatile versus IV anesthesia for cancer surgery

Lasting impact of general anaesthesia on the brain: mechanisms and relevance

PAIN MANAGEMENT

Pain Intensity on the first day after surgery

Sex differences in pain

Perioperative single dose systemic dexamethasone for postoperative pain

Effect of systemic α2 agonists on postoperative morphine consumption and pain intensity

Impact of perioperative dexamethasone on postoperative analgesia and side-effects

Combining paracetamol with nonsteroidal anti-inflammatory drugs

The prevention of chronic postsurgical pain using gabapentin and pregabalin

Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty

REGIONAL ANAESTHESIA

The analgesic efficacy of pre‐operative bilateral erector spinae plane (ESP) blocks

Adductor canal block versus femoral nerve block for total knee arthroplasty

Pectoral nerves I and II blocks in multimodal analgesia for breast cancer surgery

NAP3 – neuraxial complications

MASTER

GOOD ANAESTHESIA PRACTICE

PROFESSIONALISM

Perioperative fasting in adults and children (ESA, 2011)

Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration (2011)

Recommendations for standards of monitoring during anaesthesia and recovery (AAGBI, 2015)

SAFETY & QUALITY

PROXI

PERIOPERATIVE CARE

INTENSIVE CARE MEDICINE

PERIOPERATIVE MEDICINE

POISE

High STOP-Bang score indicates a high probability of obstructive sleep apnoea

Myocardial injury after noncardiac surgery

Effect of anaesthetic technique and other perioperative factors on cancer recurrence

Reduced length of hospital stay in colorectal surgery after implementation of an enhanced recovery protocol

TRAUMA

CRASH-2

CRASH

SPECIALTY PATIENT GROUPS

OBSTETRICS

WOMAN

The risk of cesarean delivery with neuraxial analgesia given in early versus late in labor

Fetal and maternal effects of phenylephrine and ephedrine during spinal anaesthesia for cesarean delivery

Regional versus general anaesthesia for caesarean section

PAEDIATRICS

The GAS trial

Association between a single general anesthesia exposure before age 36 months and neurocognitive outcomes in later childhood

Cognitive and behavioral outcomes after early exposure to anesthesia and surgery

Long-term differences in language and cognitive function after childhood exposure to anesthesia

Association of anesthesia and surgery during childhood with long-term academic performance

Early childhood exposure to anesthesia and risk of developmental and behavioral disorders

Attention-deficit/hyperactivity disorder after early exposure to procedures requiring general anesthesia

Regional (spinal, epidural, caudal) versus general anaesthesia in preterm infants

Prospective multi-centre RCT of cuffed or unruffled endotracheal tubes in small children

SURGICAL SPECIALTIES

ANAESTHESIA IN OUTSIDE AREAS

CARDIAC SURGERY, INTERVENTIONAL CARDIOLOGY

ATACAS

Point-of-care testing in coagulopathic cardiac surgery patients

Coagulation factor concentrates combined with point-of-care coagulation testing in cardiac surgery

Dexmedetomidine versus propofol sedation reduces delirium after cardiac surgery

Protection by remote ischemic preconditioning with isoflurane but not propofol

GENERAL SURGERY, UROLOGY, GYNAECOLOGY, ENDOSCOPY

High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery

HEAD & NECK, EAR, NOSE & THROAT, DENTAL SURGERY

NEUROSURGERY, NEURORADIOLOGY

AnStroke

Conscious sedation vs general anesthesia on early neurological improvement among patients with ischemic stroke undergoing endovascular thrombectomy

PAPERS