Key practice-changing papers to be familiar with for the part II exam, in order of publication year
PADDI
- In progress
BALANCED
- In progress
RELIEF
- Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery
- N Engl J Med. DOI: 10.1056/NEJMoa1801601.
- Available at https://www.nejm.org/doi/10.1056/NEJMoa1801601
NAP6 – anaphylaxis
- National Audit Project 6 – anaesthesia, surgery and life-threatening allergic reactions
- RCOA UK 2018
- Available at www.nationalauditprojects.org.uk/NAP6home
WOMAN
- Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage: an international, randomised, double-blind, placebo-controlled trial
- Lancet 2017; 389: 2105-16
ATACAS
- Aspirin and tranexamic acid for coronary artery surgery
- N Engl J Med 2017; 376: 136-148 (tranexamic acid in patients undergoing coronary-artery surgery)
- N Engl J Med 2016; 374(8): 728-37 (stopping vs. continuing aspirin before coronary artery surgery)
GAS
- A multi-site randomized controlled trial comparing regional and general anesthesia for effects on neurodevelopmental outcome and apnea in infants
- Lancet 2016; 387: 239–250 (neurodevelopment)
- Anesthesiology 2015; 123: 38-54 (apnoea)
THRIVE
- Transnasal Humidified Rapid-Insufflation Ventilatory Exchange: a physiological method of increasing apnoea time in patients with difficult airway
- Anaesthesia 2015; 70(3) 323-329
ENIGMA II
- The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery: a randomised, single blinded trial
- Lancet 2014; 384: 1446-54
POISE II
- Aspirin in patients undergoing noncardiac surgery
- NEJM 2014; 370(16):1494-1503
NAP5 – awareness
- National Audit Project 5 – awareness
- RCOA UK 2014
- Available at www.nationalauditprojects.org.uk/NAP5home
REASON
- Postoperative complications in Australia and New Zealand
- Periop Med 2013; 2:16
NAP4 – airway complications
- National Audit Project 4 – airway complications
- RCOA UK 2011
- Available at www.nationalauditprojects.org.uk/NAP4_home
CRASH-2
- Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage
- The Lancet 2010; 376(9734): 23-32
Prospective multi-centre RCT of cuffed or unruffled endotracheal tubes in small children
- Br J Anaesth 2009; 103(6): 867-73
PROXI
- Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial
- JAMA 2009; 14;302(14): 1543-50
NAP3 – neuraxial complications
- National Audit Project 3 – neuraxial complications
- RCOA UK 2009
- Available at www.nationalauditprojects.org.uk/NAP3_home
GALA
- General anaesthesia versus local anaesthesia for carotid surgery: a multicentre, randomised controlled trial
- Lancet 2008; 372: 2132-42
POISE
- Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery: a randomised controlled trial
- Lancet 2008; 371: 1839-47
ENIGMA
- Risk factors for severe postoperative nausea and vomiting in a randomized trial of nitrous oxide-based vs nitrous oxide-free anaesthesia
- Br J Anaesth 2008; 101: 498-505
The risk of cesarean delivery with neuraxial analgesia given in early versus late in labor
- NEJM 2005 Feb 17;352(7):655-65
B-AWARE
- Bispectral index monitoring to prevent awareness during anaesthesia: the B-Aware randomised controlled trial
- Lancet 2004; 363: 1757-63.
CRASH
- Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury: randomised placebo-controlled trial
- Lancet 2004; 364: 1321-8
SAFE
- A comparison of albumin and saline for fluid resuscitation in the intensive care unit
- NEJM 2004; 350(22):2247-2256.
MASTER
- Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial
- Lancet 2002; 359: 1276-82
Fetal and maternal effects of phenylephrine and ephedrine during spinal anaesthesia for cesarean delivery
- Anesthesiology 2002; 97(6):1582-90